Select Publications & Patents

Below are some academic publications and patents from the team. As drug discovery and development is our major focus, much of our work first contributes to patents and regulatory applications for novel therapeutics, with academic publications following later. So, in addition to the below, take a look at our Research section to learn more about our current research.

Research

2022

Bowen MT, George O, Muskiewicz DE, Hall FS. Factors contributing to the escalation of alcohol consumption. Neuroscience & Biobehavioral Reviews.

Rehn S, Raymond JS, Boakes R, Bowen MT. Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day. Psychopharmacology.

Milligan CJ, Anderson LL, Bowen MT, Banister D, McGregor IS, Arnold C, Petrou S. A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function. Journal of Cannabis Research.

Patent family

Bowen MT, McGregor IS, Kassiou M, Jorgensen W, Hicks C. Therapeutic compounds and compositions for treating social disorders and substance use disorders.

Granted US Patent (Patent No. 11033555)
Granted Australian Patent (Patent No. 2016289271)
Brazilian Patent Application Under Examination (Patent App. No. BR1120180000590)
Canadian Patent Application Exam Requested (Patent App. No. 2991236)
Chinese Patent Granted (Patent No. ZL201680040337.2)
European Patent Allowed (Patent No. 16820570.6)
Hong Kong Patent Awaiting Grant Recordal (Patent No. 18112118.2)
Indian Patent Application Under Examination (Patent App. No. 201717046363)
Israeli Patent Accepted (Patent No. 256684)
Japanese Patent Granted (Patent No. 2018-500416)
Mexican Patent Granted (Patent No. 389545)
New Zealand Patent Application Examination Complete (Patent App. No. 738672)
Republic of Korean Patent App. Exam Requested (Patent App. No. 10-2018-7003161)
South African Patent Application Filed (Patent App. No. 2018/00530)

Patent family

Bowen MT, McGregor IS, Baracz SJ, Cornish JL. Methods for management of weight.

US Patent Application Published (Patent App. No. 17/295638)
Australian Patent Application Published (Patent App. No. 2019383052)

Patent family

Kassiou M, Jorgensen W, Reekie T, Werry E, Bowen MT, McGregor IS. Non-peptide oxytocin receptor agonists

Australian Patent Accepted (Patent No. 2017377653)
Brazilian Patent Application Under Examination (Patent App. No. BR1120190120491)
Canadian Patent Application Filed (Patent App. No. 3046809)
Chinese Patent Application Under Examination (Patent App. No. 201780085825.X)
European Patent Application Under Examination (Patent App. No. 17880082.7)
Hong Kong Patent Application Filed (Patent App. No. 62020004269.0)
Indian Patent Application Under Examination (Patent App. No. 201917026397)
Israeli Patent Application Under Examination (Patent App. No. 267276)
Japanese Patent Accepted (Patent No. 2019-531447)
Mexican Patent Application Under Examination (Patent App. No. MX/a/2019/006942)
New Zealand Patent Application Filed (Patent App. No. 754890)
Republic of Korean Patent App. Exam Requested (Patent App. No. 10-2019-7019977)
South African Patent Application Filed (Patent App. No. 2019/04290)
US Patent Application Under Examination (Patent App. No. 16/439570)

2021

Raymond JS, Rehn S, Hoyos CM, Bowen MT. The influence of oxytocin-based interventions on sleep-wake and sleep-related behaviour and neurobiology: a systematic review of preclinical and clinical studies. Neuroscience & Biobehavioral Reviews

Smith AS, Jurek B, Grinevich V, Bowen MT. The oxytocin system in fear, stress, anguish and pain. Frontiers in Endocrinology

Anderson LL, Heblinski M,... Bowen MT... Kearney JA, Arnold JC. Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy. British Journal of Pharmacology

Martin LJ, Cairns EA... Bowen MT, Anderson LL. Cannabichromene and Δ9-Tetrahydrocannabinolic Acid Identified as Lactate Dehydrogenase-A Inhibitors by in Silico and in Vitro Screening. Journal of Natural Products

Martin LJ, Banister SD, Bowen MT. Understanding the complex pharmacology of cannabidiol: mounting evidence suggests a common binding site with cholesterol. Pharmacological Research

Patent family

Bowen MT, McGregor IS. Treatment of opioid withdrawal

Australian Patent Application (Patent App. No. 2020343726)
Brazilian Patent Application (Patent App. No. BR112022003889.5)
Canadian Patent Application (Patent App. No. 3150103)
Chinese Patent Application (Patent App. No. 202080062769.X)
European Patent Application Under Examination (Patent App. No. 20861856.1)
Hong Kong Patent Application (Patent App. No. )
Indian Patent Application (Patent App. No. 201917026397)
Israeli Patent Application (Patent App. No. 291065)
Japanese Patent Application (Patent No. 2022-515554)
Mexican Patent Application (Patent App. No. MX/a/2022/002751)
New Zealand Patent Application (Patent App. No. 785640)
Republic of Korean Patent Application (Patent App. No. 10-2022-7011111)
South African Patent Application (Patent App. No. 2022/02728)
US Patent Application (Patent App. No. 17/637512)

2020

Martin L & Bowen MT. Comparing fingerprints for ligand-based virtual screening: a fast, scalable approach for unbiased evaluation. Journal of Chemical Information and Modeling

Absalom N, Liao V,… Bowen MT… Dale R, Chebib M. Gain-of-function GABRB3 variants identified in vigabatrin-hypersensitive epileptic encephalopathies. Brain Communications

Tan O, Martin LJ, Bowen MT. Divergent pathways mediate 5-HT1A receptor agonist effects on close social interaction, grooming and aggressive behaviour in mice: Exploring the involvement of the oxytocin and vasopressin systems. Journal of Psychopharmacology

2019

Raymond JS, Wilson BB, Tan O, Gururajan A, & Bowen MT. Acute alcohol exposure dose-dependently alleviates social avoidance in adolescent mice and inhibits social investigation in adult mice. Psychopharmacology.

Bowen MT. Does peripherally administered oxytocin enter the brain? Compelling new evidence in a long-running debate. Pharmacological Research.

Tan O, Musullulu H, Raymond JS, Wilson B, Langguth M, Bowen MT. Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice. Neuropharmacology

Absalom NL,… Bowen MT, Chebib M. Functional genomics of epilepsy-associated mutations in the GABAA receptor subunits reveal that one mutation impairs function and two are catastrophic. Journal of Biological Chemistry.

Martin L & Bowen MT. The missing label problem: addressing false assumptions improves ligand-based virtual screening. ChemRxiv

2011 - 2018

Bowen MT, Neumann ID (2018). The multidimensional therapeutic potential of targeting the brain oxytocin system for the treatment of substance use disorders. Current Topics in Behavioral Neurosciences.

Meiser B,… Bowen MT, Mills L, Kirk J (2018). Psychological outcomes and surgical decisions after genetic testing in women newly diagnosed with breast cancer with and without a family history. European Journal of Human Genetics.

Bowen MT with World Economic Forum Young Scientists Community (2018). Code of Ethics for Researchers. World Economic Forum, Geneva, Switzerland.

Bowen MT, Neumann ID (2017). Rebalancing the addicted brain: Oxytocin interference with the neural substrates of addiction (Feature Review). Trends in Neurosciences

Bowen MT, Peters ST, McGregor IS, Neumann ID (2017). Oxytocin inhibits ethanol consumption and ethanol-induced dopamine release in the nucleus accumbens. Addiction Biology

Suraev AS, Todd L, Bowen MT, Allsop D, McGregor IS, Ireland C, Lintzeris N (2017). An Australian nationwide survey on medicinal cannabis use for epilepsy: History of antiepileptic drug treatment predicts medicinal cannabis use. Epilepsy and Behavior

Quinn VF,… Bowen MT, Mitchell G (2017). Streamlined genetic education is effective in preparing women newly diagnosed with breast cancer for decision-making about treatment-focused genetic testing: A randomised controlled non-inferiority trial. Genetics in Medicine.

Bowen MT (2017). As scientists, we must fight fake news with truth. World Economic Forum Agenda.

Bowen MT (2017). The Selfish Gene: A book that helped shape my thinking. Sydney University Alumni Magazine

Bowen MT, Liu J, Buisman-Pijlman FTA (2016). Oxytocin: providing new avenues for treating and understanding problematic drug use. In V. Preedy (Ed.), The Neuropathology of Drug Addictions and Substance Misuse. Academic Press: London.

Bowen MT, Peters ST, Absalom N, Chebib M, Neumann ID, McGregor IS (2015). Oxytocin prevents ethanol actions at δ subunit-containing GABAA receptors and attenuates ethanol-induced motor impairment in rats. Proceedings of the National Academy of Sciences.

Bowen MT, McGregor IS (2015). Could research into oxytocin and alcohol lead to a ‘sobriety pill’? The Conversation.

Patent family

Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.

US Patent US9119805B2 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.
Australian Patent 2010302945 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.
European Patent EP2482835B1 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.
German Patent 2482835 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.
Irish Patent 2482835 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.
Italian Patent 2482835 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.
Spanish Patent 2482835 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.
Swedish Patent 2482835 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.
UK Patent 2482835 (Granted). Bowen MT, McGregor IS, Carson DS, Guastella A. Therapy and Prevention of Problem Drinking.

Bowen MT, McGregor IS (2014). Oxytocin and vasopressin modulate the social response to threat: a preclinical study. The International Journal of Neuropsychopharmacology.

Bowen MT, Hari Dass SA, Booth J, Suraev A, Vyas A, McGregor IS (2014). Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system. Hormones and Behavior.

Suraev AS, Bowen MT, Ali SO, Hicks C, Ramos L, McGregor IS (2014). Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood. Hormones and Behavior.

Bowen MT (2014). Miscellaneous Hormones. In S. Ray (Ed.), Side Effects of Drugs Annual 36. Elsevier: Netherlands, 659-673.

Bowen MT, Kevin RC, May M, Staples LG, Hunt GE, McGregor IS (2013). Defensive aggregation (huddling) in Rattus norvegicus toward predator odor: Individual differences, social buffering effects and neural correlates. PLoS One

Motbey CP,… Bowen MT, Cornish JL, McGregor IS (2013). High levels of intravenous mephedrone self-administration in rats: Neural consequences and comparison with methamphetamine. Journal of Psychopharmacology.

McGregor IS, Bowen MT (2013). Oxytocin and addiction: recent preclinical advances and future clinical potential. In E. Choleris, D. Pfaff, & M. Kavaliers (Eds.), Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior. Cambridge, UK: Cambridge University Press, 270-287.

Bowen MT, Keats K, Kendig MD, Cakic V, Callaghan PD, McGregor IS (2012). Aggregation in quads but not pairs of rats exposed to cat odor or bright light. Behavioural Processes

May M, Bowen MT, McGregor IS, Timberlake W (2012). Rubbings deposited by cats elicit defensive behavior in rats. Physiology and Behavior.

McGregor IS, Bowen MT (2012). Breaking the loop: Oxytocin as a potential treatment for drug addiction. Hormones and Behavior.

Bowen MT, Carson DS, Spiro A, Arnold JC, McGregor IS (2011). Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats. PLoS ONE.

Motbey CP, Hunt GE, Bowen MT, Artiss S, McGregor IS (2011). Mephedrone (4-Methylmethcathinone, "Meow"): Acute Behavioural Effects and Distribution of Fos Expression in Adolescent Rats. Addiction Biology.

Kendig MD, Bowen MT, Kemp AH, McGregor IS (2011). Predatory threat induces huddling in adolescent rats and residual changes in early adulthood suggestive of increased resilience. Behavioural Brain Research